Dr. Michael E. Kovach earned his B.S. from Baldwin-Wallace College and his Ph.D. in Microbiology from Louisiana State University Medical Center – Shreveport (now, Louisiana State University Health Science Center - Shreveport). His teaching responsibilities at Baldwin-Wallace College include Microbiology, Immunology, Freshman Biology Seminar and on occasion, non-majors Biology and Sophomore Biology Seminar. Dr. Kovach’s doctoral and post-doctoral research focused on how bacteria are able to cause disease (bacterial pathogenesis) and his post-doctoral work investigated the importance of DNA repair in intracellular survival of the Gram-negative pathogen, Brucella abortus. His research with B-W students continues to explore the importance of DNA repair in intracellular survival of Brucella. His research at Baldwin-Wallace College is currently supported by a grant from The Alma M. & Harry R. Templeton Medical Research Foundation.
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Grant Support and Publications:
Publications:
Roux, CM, N.J. Booth, B.H. Bellaire, J.M. Gee, R. M. Roop II, M. E. Kovach, R.M. Tsolis, P.H. Elzer, D.G. Ennis. Evaluation of the roles of the DNA repair protein RecA and RadA in the pathogenesis of Brucella abortus. J. Bacteriology (Submitted – December 2005)
Gee, J.M., M.W. Valderas, M. E. Kovach, V. K. Grippe, G.T. Robertson, W.L. NG, J.M. Richardson, M.W. Winkler and R. M. Roop II. 2005. The Brucella abortus Cu/Zn superoxide dismutase (SodC) is required for optimal resistance to oxidative killing by murine macrophages and wild type virulence in experimentally infected mice. Infect. Immun. 73(5):2873-2880.
Gee, J.M., M. E. Kovach, V.K. Grippe, S. Haguis, J. V. Walker, P.H. Elzer, and R. M. Roop II. 2004. Role of catalase in the virulence of Brucella melitensis in pregnant goats. Veterinary Microbiology 102:111-115.
Robertson, G.T., M.E. Kovach, C. Allen, T.A. Ficht and R.M. Roop II. 2000. The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice. Mol. Microbiol. 35(3):577-588.
Faculty-Student Collaborative Scholarship:
(Student authors indicated by blue text)
Moreno, S.E. and M.E. Kovach. Unlocking the pathogenesis of Brucella abortus through DNA repair. Bridges to Success in the Sciences Poster Session. Cuyahoga Community College, Cleveland Ohio. July 30, 2002.
Moreno, S.E, R.J. Braydich, M.E. Kovach. Cloning and complementation of the Brucella abortus O6-methylguanine-DNA methyltransferase (ada) involved in the adaptive response to alkylating DNA damage. Spring Science Poster Session. Baldwin-Wallace College, Berea Ohio. April 2002.
Moreno, S.E and M.E. Kovach. Cloning and complementation of the Brucella abortus O6-methylguanine-DNA methyltransferase (ada) involved in the adaptive response to alkylating DNA damage. Bridges to Success in the Sciences Poster Session. Cuyahoga Community College, Cleveland Ohio. April 26, 2002.
Grant Support/Funding:
2003 Baldwin-Wallace College Gund Summer Grant: "Functional analysis of the Brucella abortus ada & alkA in Escherichia coli and the generation and characterization of Brucella abortus ada and alkA mutants" - $2,993
2000 Baldwin-Wallace College Gund Summer Grant: " Identification & isolation of the Brucella abortus Exonuclease III (xthA), Endonuclease IV (nfo) and Endonuclease V (nfi) genes." $3,000
2000 Baldwin-Wallace College Gund Multi-media Grant: "Production of an Electronic Laboratory Manual for the Microbiology Course" - $1,000
1999 - 2001 The Alma M. & Harry R. Templeton Medical Research Foundation: "The Role of Brucella DNA Repair Enzymes in Brucella Pathogenesis" - $45, 000.
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